Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21
نویسندگان
چکیده
منابع مشابه
Acute megakaryoblastic leukemia and clonal trisomy 21 in a phenotypically normal infant.
Kojima et al recently reported 20 patients with Down’s syndrome and acute leukemia.’ Of these 20 patients, 14 who were 3 years old and less were diagnosed as having acute megakaryoblastic leukemia (AMKL). They were characterized by the presence of bone marrow fibrosis, a history of myelodysplastic syndrome (MDS), and a poor response to chemotherapy. Ten of the 14 patients were male, and platele...
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BACKGROUND It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids. METHODS We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years. The cytogenetic analysis r...
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Trisomy 21 mosaicism in a woman with two children with trisomy 21 Down's syndrome* Summary. Trisomy 21 mosaicism was identified by fluorescent quinacrine banding in a phenotypically normal mother, who gave birth to two children with trisomy 21 Down's syndrome. Trisomy 21 Down's syndrome associated with maternal mosaicism was first described by Smith et al in 1962. Since then there have been at ...
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Copyright © SLACK Incorporated A10-year-old boy with Trisomy 21 presented to the emergency department with a history of rash on his legs, easy bruising and bleeding, and walking with a limp. One month prior to presentation, he had developed a non-pruritic, non-painful, petechial rash on his lower legs (Figure 1). Eczema was suspected and he was treated with a topical steroid cream, but there wa...
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We review the published reports on reproduction in cases of non-mosaic trisomy 21 (Down's syndrome) and present the first fully documented case of a non-mosaic male with Down's syndrome fathering a pregnancy, a fact which has important implications in the light of caring for these people in the community.
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ژورنال
عنوان ژورنال: Case Reports in Pediatrics
سال: 2020
ISSN: 2090-6803,2090-6811
DOI: 10.1155/2020/7813048